The men are excited that Bill Gates is visiting Penny's pharmaceutical company, although she says that she cannot bring them along. Sheldon believes that it's an April Fools' Day prank. Leonard sees what hotel Gates is staying at on Penny's schedule, so he, Raj and Howard meet him in the lobby the day before. Once Sheldon sees proof, the men twice send him to the wrong hotel as real pranks. Penny says Leonard can meet Gates for real, so he fakes being sick to avoid him. When Penny puts Gates on a video call, he recognizes Leonard from the previous night. Meanwhile, Amy is tired of Bernadette only talking about her children, so Bernadette uses her expanded parental brain to learn random science facts.
Leonard gives an interview on public radio where he admits physics research might be at a dead end. The university is furious and, while trying to think of reasons to put in a retraction, he depresses Sheldon into thinking he might be right. Howard and Raj come over and end up just as depressed. Getting drunk with Penny, the men go to the grave of Richard Feynman and realize there is hope for physics as long as they believe in it. Leonard accidentally sends a drunken email to Human Resources. Meanwhile, Amy and Bernadette agree with each other to keep quiet about the success in their careers so as not to upset Sheldon and Howard. While bragging to each other, they end up arguing which of their fields is better.

When Mayim Bialik first learned she had to say goodbye to neurobiologist Amy Farrah Fowler, she opened up about the show ending in a blog post, asking, "And now I start to figure out what next. Where will life take me? Where will this career go? What do I want?" Up next she has a voice role in The Inspector Chronicles, a quasi-parody of Doctor Who making the leap from short to feature film. She'll reprise her role as the voice of the Inspector's time machine, known as B.O.O.T.H. Aside from that, she doesn't have any major projects lined up, aside from preparing to not see her close-knit cast the way she'd grown accustomed to. "We'll have to see what our lives look like," she told Us Weekly in early May about the chance they'll remain close. "I mean, we're all going to be on different schedules now; it's very different."
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Two physicists from Chicago, Dr. Campbell and Dr. Pemberton, accidentally prove Sheldon and Amy's super-asymmetry theory. This puts them on track for a Nobel Prize, but Leonard points out they tend to go to the experimental scientists who prove a concept instead of theorists like Sheldon who come up with it. Meeting with them, they tell Sheldon they are willing to share the Prize but only three names can be on the submission, and they want to cut Amy out. Amy does not want to prevent Sheldon's lifelong dream, but he goes to President Seibert who agrees to fight for Amy on their behalf. Meanwhile, Bernadette's drug has been approved and she wants to promote Penny to lead the marketing team. Penny resists, knowing Bernadette's attitude at work and doubting her own inexperience to take the responsibility, but Bernadette uses reverse-psychology to get Penny to take the job. Penny mirrors Bernadette's commanding style to get the other employees in line, impressing Bernadette.

Sheldon and Amy struggle to choose a best man and maid of honor from their friends. They secretly decide to test and score them, allowing everyone to have an equal shot at either role. Once the gang finds out, none of them apart from Bernadette and Stuart want to be in the wedding. Sheldon settles for Stuart as best man but, once Leonard tells Sheldon that, as the groom, the decision is his alone, he picks Leonard. Amy is set to call Bernadette but, once Penny realizes Amy is her best friend, she immediately pitches herself for the position and Amy enthusiastically chooses her. Amy later makes Penny tell Bernadette the bad news.

Penny runs into her ex-boyfriend Zack, who has gotten rich from selling his company and married a similarly dim-witted woman named Marissa. Meeting with Leonard and Penny, they say Zack is infertile and ask to pay Leonard as a sperm donor so they can have a baby. Leonard is flattered, but Penny finds it creepy. Leonard says that since Penny decided she did not want to have children, he should be allowed to help another couple with this issue. Sheldon advises him to think about the emotional toll this could have on him. Leonard says he will not do it if Penny objects; Penny says she will support whatever decision Leonard makes. Meanwhile, Raj tries to get Anu back but she points out he just wanted to be married like his friends. Raj points out that Anu is similarly looking for a quick marriage. He admits to Anu that he really likes her and they decide to start their relationship as just dating.
Howard dresses as Sheldon for Halloween at work, hurting Sheldon's feelings. When Howard does not apologize, Amy and Sheldon dress as Bernadette and Howard at Penny and Leonard's party, angering Bernadette. Sheldon and Bernadette later bond over their painful childhood memories. Leonard is upset that Penny does not seem to remember that their first kiss was on Halloween. Penny later admits she does remember, but does not like to think of their first kiss as an unromantic drunken hookup. She likes to imagine their first kiss was one they shared on Leonard's birthday, which pleases him.
While Jim Parsons was the one who'd had enough with The Big Bang Theory, opting not to renew his contract to play socially awkward theoretical physicist Sheldon Cooper and bringing about the demise of the show in the process, he won't be escaping the show's orbit entirely. He's still attached as both executive producer and narrator of prequel series Young Sheldon, returning for a third season on CBS this fall. "There was no factor; there was no situation that I was like, 'Well, I've had enough of that.' No. There was nothing like that. It was just…when you know, you know," he explained to The Hollywood Reporter in mid-May. 

With Leonard, Howard, Raj, and Amy accomplishing so much on their respective projects, Sheldon is forced to admit he has nothing important upon which to work. He makes Amy leave the apartment for a few days so he can focus, but cannot come up with any ideas and calls his mother as a distraction. Leonard and Amy have fun recreating experiments from when they were growing up, boring Penny, so she eats with Sheldon as he mulls over his scientific studies. Penny helps him realize that his study of dark matter is his rebound science from string theory, which Sheldon admits he never truly disregarded, but explaining string theory to her inspires Sheldon, helping him discover a potential breakthrough in the field. Meanwhile Howard is too busy with his family to be in the band with Raj, so Raj brings in Bert. But, when Howard annoys Bernadette by writing an astronaut-themed musical while she is on bed-rest, she makes him rejoin the band. The three are poorly received at a Bar mitzvah after singing Bert's original song about the boulder from Indiana Jones .
Sheldon and Amy's wedding day arrives, with many friends and family attending, including Amy's domineering mother (Kathy Bates) and quiet father (Teller); Sheldon's mother Mary, brother George, and sister Missy, who is pregnant with her second child and separated from her husband; and Mark Hamill, who replaces Wil Wheaton as officiant as a favor to Howard who returned his lost dog. Sheldon cannot get his bow-tie to be symmetrical and conversations with Amy and his mother give him an epiphany about superasymmetry. Sheldon and Amy, along with Leonard, get caught up figuring out the math of the theory during the wedding ceremony, making Hamill take Star Wars questions to stall for time. Penny retrieves the couple, who then decide that they have the rest of their lives to make science together. Amy and Sheldon then express their vows. Amy recites a set of heartfelt vows, leaving Sheldon initially at a loss for words, before he reciprocates her loving words. They are pronounced as husband and wife.
Sheldon and Amy's wedding day arrives, with many friends and family attending, including Amy's domineering mother (Kathy Bates) and quiet father (Teller); Sheldon's mother Mary, brother George, and sister Missy, who is pregnant with her second child and separated from her husband; and Mark Hamill, who replaces Wil Wheaton as officiant as a favor to Howard who returned his lost dog. Sheldon cannot get his bow-tie to be symmetrical and conversations with Amy and his mother give him an epiphany about superasymmetry. Sheldon and Amy, along with Leonard, get caught up figuring out the math of the theory during the wedding ceremony, making Hamill take Star Wars questions to stall for time. Penny retrieves the couple, who then decide that they have the rest of their lives to make science together. Amy and Sheldon then express their vows. Amy recites a set of heartfelt vows, leaving Sheldon initially at a loss for words, before he reciprocates her loving words. They are pronounced as husband and wife.
^ "Editor's Note: With final Monday ratings in, The Big Bang Theory has now reached a new series high in viewers (16.32m) and was the night's top program in adults 18-49 (5.9/15), up a tenth from this morning. -- "Two and a Half Men" Soars to Its Best Adult 18-49 Rating in Three Years". CBS. March 9, 2010. Archived from the original on January 8, 2014. Retrieved January 5, 2013.
Producers, writers and others, including recurring guest star Wil Wheaton, joined the festivities on set and — hardly a spoiler alert — more laughing, crying and hugging ensued. Lorre embraced a happy Parsons, then moved on to each cast member as if it were a reception line. Galecki shared long, emotional hugs with his colleagues. After trying to keep their emotions under control for so long, it was finally time to just let go.
^ Jump up to: a b Kondolojy, Amanda (October 12, 2014). "'Gotham' Has Biggest Adults 18–49 Ratings Increase; 'Gotham' & 'Red Band Society' Top Percentage Gains & 'How To Get Away With Murder' Tops Viewer Gains in Live +7 Ratings for Week Ending September 28". TV by the Numbers. Archived from the original on October 16, 2014. Retrieved October 13, 2014.

Sheldon and Amy are surprised to find that Wil Wheaton's new Professor Proton show is actually very entertaining and that Wil had Howard on as a guest. On Howard's suggestion, Sheldon apologizes to Wil, mending their friendship, and tells him he wants to be on the show; but Wil asks for Amy. Sheldon tells her to do it, but she says she often doesn't do things to avoid upsetting him. Sheldon is horrified when he realises how selfish he has been, especially when he finds out that the men do the same for him. Sheldon encourages Amy to go on the show to inspire girls to pursue science while trying to control his obvious jealousy for her. Meanwhile, Leonard writes a book about a physicist that solves a murder, the protagonist Logan Dean is based on himself. Bernadette points out Logan's mean boss Illsa is similar to Penny, who thinks it is based on Bernadette, though Leonard does not correct her. However, Bernadette tells Penny the truth, upsetting her and making her mad at Leonard. After calling his mother for advice, Leonard learns that Illsa is actually like her; but abandons the book when he realizes he wrote romantic tension into the relationship between the characters.
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